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Amitriptyline
Brand Name: Amitriptyline
Generic Name: Elavil; Endep (a mee trip' ti leen)
Drug Class: ANTIDEPRESSANTS
Why is Amitriptyline prescribed?
Amitriptyline, an antidepressant (mood elevator), is used to treat depression.
Amitriptyline is sometimes prescribed for other uses; ask your doctor or pharmacist for more information.
How should Amitriptyline be used?
Amitriptyline comes as a tablet to take by mouth. It is usually taken one to four times a day and may be taken with or without food. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take amitriptyline exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.
Continue to take amitriptyline even if you feel well. Do not stop taking amitriptyline without talking to your doctor, especially if you have taken large doses for a long time. Your doctor probably will want to decrease your dose gradually. This drug must be taken regularly for a few weeks before its full effect is felt.
Other uses for Amitriptyline:
Amitriptyline also is used occasionally to treat chronic pain and eating disorders. Talk to your doctor about the possible risks of using this drug for your condition.
What special precautions should I follow?
Before taking amitriptyline,
- tell your doctor and pharmacist if you are allergic to amitriptyline or any other drugs.
- tell your doctor and pharmacist what prescription and nonprescription drugs you are taking or have taken within the last 2 weeks, especially anticoagulants [warfarin (Coumadin)]; antihistamines; cimetidine(Tagamet); estrogens; fluoxetine (Prozac); cisapride (Propulsid); levodopa (Sinemet, Larodopa); lithium (Eskalith, Lithobid); MAO inhibitors [phenelzine (Nardil), tranylcypromine (Parnate)]; medication for high blood pressure, seizures, Parkinson's disease, diabetes, asthma, colds, or allergies; methylphenidate (Ritalin); muscle relaxants; oral contraceptives; sedatives; sleeping pills; thyroid medications; tranquilizers; and vitamins.
- tell your doctor if you have or have ever had glaucoma, an enlarged prostate, difficulty urinating, seizures, an overactive thyroid gland, or liver, kidney, or heart disease.
- tell your doctor if you are pregnant, plan to become pregnant, or are breast-feeding. If you become pregnant while taking amitriptyline, call your doctor immediately.
- if you are having surgery, including dental surgery, tell the doctor or dentist that you are taking amitriptyline.
- you should know that this drug may make you drowsy. Do not drive a car or operate machinery until you know how this drug affects you.
- remember that alcohol can add to the drowsiness caused by this drug.
- tell your doctor if you use tobacco products. Cigarette smoking may decrease the effectiveness of this drug.
What special dietary instructions should I follow?
Your doctor may instruct you to follow a low-sodium, low-salt, potassium-rich, or high-protein diet. Follow these directions.
If you experience stomach pain or upset stomach, you may take this medication with food or milk.
What should I do if I forget a dose?
If you take several doses per day, take the missed dose as soon as you remember it and take any remaining doses for that day at evenly spaced intervals. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule.
If you take amitriptyline once a day at bedtime and do not remember to take it until the next morning, skip the missed dose. Do not take a double dose to make up for a missed one.
What side effects can Amitriptyline cause?
Side effects from amitriptyline are common:
- upset stomach
- drowsiness
- weakness or tiredness
- excitement or anxiety
- insomnia
- nightmares
- dry mouth
- skin more sensitive to sunlight than usual
- changes in appetite or weight
Tell your doctor if any of these symptoms are severe or do not go away:
- constipation
- difficulty urinating
- frequent urination
- blurred vision
- changes in sex drive or ability
- excessive sweating
If you experience any of the following symptoms, call your doctor immediately:
- jaw, neck, and back muscle spasms
- slow or difficult speech
- shuffling walk
- persistent fine tremor or inability to sit still
- fever
- difficulty breathing or swallowing
- severe skin rash
- yellowing of the skin or eyes
- irregular heartbeat
What storage conditions are needed for Amitriptyline?
Keep Amitriptyline in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom). Throw away any medication that is outdated or no longer needed. Talk to your pharmacist about the proper disposal of your medication.
In case of emergency/overdose
In case of overdose, call your local poison control center at 1-800-222-1222. If the victim has collapsed or is not breathing, call local emergency services at 911.
Symptoms of overdose may include:
- irregular hearbeat
- seizures
- coma
- confusion
- problems concentrating
- seeing things that do not exist (hallucinating)
- agitation
- drowsiness
- rigid muscles
- vomiting
- fever
- cold body temperature
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